Acetaminophen, also known as Tylenol, is used to help with pain & to reduce fever. However, taking too much acetaminophen can be harmful to the liver which filters out toxins & Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Frontiers MitochondrialLysosomal Axis in Acetaminophen Hepatotoxicity How Acetaminophen Causes Liver Failure Biocompare: The Buyer's Guide for Life Scientists Acetaminophen detoxification in cucumber plants via induction of glutathione S transferases ScienceDirect Electrochemical evidences in oxidation of acetaminophen in the presence of glutathione and N acetylcysteine Chemical Communications (RSC Publishing)