The molecular mechanisms of acetaminophen induced hepatotoxicity and its potential therapeutic targets Guangwen Luo, Lili Huang, Zhaowei Zhang, 2023 Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Pharmacokinetic profile of metabolites by heart cutting two dimensional liquid chromatography: A focus on paracetamol analysis ScienceDirect Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Paracetamol (acetaminophen) toxicity occurs when the liver is overwhelmed by a toxic metabolite called N acetyl p benzoquinone imine (NAPQI), which is normally detoxified by glutathione. In overdose, glutathione is depleted, and NAPQI accumulates, leading Acetaminophen Pathway (toxic doses), Pharmacokinetics