Simple cryosurgical treatment of the oral melanotic macule ScienceDirect Oral melanotic macule and primary oral malignant melanoma: Epidemiology, location involved, and clinical implications Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule. ORAL MELANOTIC MACULE (OMM) (Also called focal melanosis labial melanotic macule) A benign, localized, flat pigmented lesion of the oral mucosa Caused by a focal increase in melanin production Happy Wednesday! , In this video, a patients labial melanotic macule (a benign pigmented lesion) is being treated with liquid nitrogen. Labial melanotic macules are flat and asymmetrical with a Labial melanotic macule