Full article: The development and hepatotoxicity of acetaminophen: reviewing over a century of progress Acetaminophen induces liver injury and depletes glutathione in mice brain: Prevention by Moringa oleifera extract ScienceDirect Minor and Short Acting Analgesics, Including Opioid Combination Products Anesthesia Key Association between acetaminophen metabolites and CYP2E1 DNA methylation level in neonate cord blood in the Boston Birth Cohort Clinical Epigenetics Springer Nature Link Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome Scientific Reports The parent compounds of acetaminophen (US market in 1955 in the US as Tylenol and other products) were first discovered in 1886 (acetanilide) and 1887 (phenacetin). These were the earliest synthetic fever