Small Molecule AngIV based Analogs to Treat Alzheimers Disease Dihexa is an experimental cognitive peptide that may help the brain build stronger connections between neurons instead of just temporarily boosting neurotransmitters like many nootropics do. It works through the HGF c Met pathway, Artificial human Met agonists based on macrocycle scaffolds Nature Communications Dihexa is an experimental cognitive peptide that may help the brain build stronger connections between neurons instead of just temporarily boosting neurotransmitters like many nootropics do. It works through the HGF c Met pathway, What if neuroplasticity research targeted the HGF c Met pathway? Dihexa (PNB 0408) is an angiotensin IVderived peptide studied in preclinical models for its role in synaptogenesis and cognitive signaling mechanisms. Human data remains limited. Structure and biologic function of HGF: HGF c MET signaling pathways Download Scientific Diagram