5 Oxoprolinuria as a Cause for Metabolic Acidosis Renal Fellow Network Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Acetaminophen Toxicity Journal of Biological Chemistry Acetaminophen Toxicity and Liver Zone Physiology [#DaVinciCases GI 5 Physiology Case 3] Tylenol And Glutathione Invigor Medical Since Tylenol is such a hot topic right now, did you know it depletes glutathione levels? When your body processes Tylenol in the liver, one of the pathways creates a toxic byproduct. To neutralize