Tylenol Glutathione Kizer Wellness LLC Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen metabolism Heres why you should avoid Tylenol , First of all, it is full of colorful dyes, sugars, and additives., But the main reason is it depletes glutathione., Glutathione is one of the most Understanding the Impact of Acetaminophen: Tylenol and Glutathione in Autism Jenny McCarthy's Glutathione and Tylenol Claims: Medical Toxicologist Weighs In MedPage Today