Liposomal Glutathione Ancient Bliss Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Thorne Glutathione SR A Comprehensive Review for Removal of Non Steroidal Anti Inflammatory Drugs Attained from Wastewater Observations Using Carbon Based Anodic Oxidation Process Tylenol and glutathione, actually explainedhere's the bullet points: * Lots of concern raised on social media re: glutathione depletion and acetaminophen use * Glutathione is used in the metabolism of acetaminophen and Reduced L Glutathione Plus (50 Caps) Buffered Setria USP Grade Enhanced Absorption Theranaturals