Does Ibuprofen Deplete Glutathione? Understanding the Connection Cymbiotika CYMBIOTIKA Glutathione Deficiency Symptoms: Is Poor Sleep Just the Beginning? Cardiology & Neurology Specialists located in Queens, Forest Hills and Brighton Beach, Brooklyn, NY Advanced Medical Care When to Use Ibuprofen vs. Tylenol for Pain Relief Is Acetaminophen or Ibuprofen better for kids? THE PEDIATRICIAN MOM Taking Tylenol? The Glutathione Connection Dr. Green Mom Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.