A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 NAPQI an overview ScienceDirect Topics How acetaminophen is metabolized in the liver Napqi hi res stock photography and images Alamy What Are the Potential Sites of Protein Arylation by N Acetyl p benzoquinone Imine (NAPQI)? Chemical Research in Toxicology Paracetamol acetaminophen hepatotoxicity: new markers for monitoring the elimination of the reactive N Acetyl p benzoquinone imine bioRxiv
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