I've posted this every year for 7 years. PSA please share. The horror stories from Tylenol (Acetaminophen) usage for children are hard to digest literally. The way my mind Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury Vliegenthart 2017 Clinical Pharmacology & Therapeutics Wiley Online Library Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Tylenol And Glutathione Invigor Medical Illustration of the effects of acetaminophen on glutathione, Download Scientific Diagram